Key Features

• Large-scale aseptic processing and lyophilization
  
• Variable batch-size capabilities (40 to 16000 liters)
  
• Automated vision inspection system

• Variable batch-size capabilities (300 to 3500 liters)
  
• Large volume tank (3000 to 40000 liters)
  
• Computer-based automated manufacturing process

• Variable batch-size mixing capabilities (300 to 3000 kg)
  
• High shear mixer
  
• Direct compaction
  
• Imprinting (debossing and embossing)

Dosage Forms

• Sterile solutions
  
• Sterile suspensions
  
• Lyophilized products (freeze-dried)

• Solutions
  
• Suspensions
  
• Creams
  
• Ointments
  
• Gels
  
• Alcohol-based solutions

• Tablets (compressed, aqueous film coated, press coated)
  
• Capsules
  
• Granules
  
• Powders

Packaging

• Vials
  
• Sterile suspensions
  
• Lyophilized products (freeze-dried)

• Solutions
  
• Suspensions
  
• Creams
  
• Ointments
  
• Gels
  
• Alcohol-based solutions

• Tablets (compressed, aqueous film coated, press coated)
  
• Capsules
  
• Granules
  
• Powders

Fluids and Ointments: Full Automation for Cost-Effective manufacturing and Packaging

Pfizer CentreSource Contract Manufacturing gives you access to our fully automated, state-of-the-art fluids and ointments facility. Reap the benefits of our fully validated, multiproduct manufacturing and packaging operation:

• More consistent product
  
• Higher yields
  
• Efficient production cycles

Operators utilize 15 different types of manufacturing equipment and produce over 60 validated products with expansion capabilities. Here's how products are typically produced:

Full Automation Flow Diagram ¹

1 Gold P, Fadel J, Mordas D, Srivastava P.Developing a successful full automation fluids and ointment facility - a case study.
Pharmaceutical Manufacturing and Packing Sourcer. 2001;March: 43-45.

We welcome the opportunity to learn about your pharmaceutical product development needs and challenges. Please contact us to explore how Pfizer's strengths and experience can exceed your goals.

Highlights of This Highly Cost-Effective Operation

Weighing

• Performed in a separate, enclosed weigh module
  
• Utilizes computerized weighing system
  
• Automates the dispensing of bulk raw materials
  
• Bar coded information is used for all material inputs
  
• Computer performs all calculations for weight and potency adjustments
  
• HEPA-filtered weigh module workstations utilize PC interfaces, bar code scanners, and label printers
  
• All information transferred to main database for efficient updating of the inventory

Manufacturing

• Production lots are scheduled using the InBatch program which schedules the appropriate equipment
  
• InBatch ensures precise control of agitation speed, vacuum, heating, and cooling of the scrape surface mixer
  
• Electronic batch record
  
• 900- to 40000-liter batch sizes
  
• Finished product held in a special staging area awaiting packaging

Cleaning

• All manufacturing tanks are cleaned in-place with a minimal amount of disassembly
  
• Cleaning agents are dispensed automatically
  
• Precise cleaning recipe used every time
  
• COP (Clean Out of Place) using specially designed recipes for all other components

Packaging

• Product transferred by means of holding tanks or direct piping feed
  
• Several packaging lines have been designed for use with numerous different product presentations
  
• All lines utilize automated systems for cap torque and fill weight control
  
• Photo eyes linked to the main computer monitor operation at several stations
  
• Packaged product is automatically palletized for transport to the warehouse